Prof. Dr. Eberhard Scholz
Prof. Dr. Eberhard Scholz ist seit Januar 2021 Chefarzt der Abteilung für Kardiologie und Angiologie der GRN-Klinik Schwetzingen.
Zum Linkedin-Profil von Prof. Dr. Scholz.
Medizinische Laufbahn:
Seit 01/2021: GRN-Klinikum Schwetzingen, Chefarzt Kardiologie und Angiologie
07/2005 – 12/2020: Universitätsklinikum Heidelberg, Innere Medizin III (Kardiologie, Angiologie und Pneumologie)
Seit 01/2018: Gesamtleitung der Elektrophysiologie
Seit 04/2017: Oberarzt der Privatstation
Seit 01/2015: Oberarzt (interventionelle Kardiologie/Elektrophysiologie)
Seit 01/2014: Facharzt für Kardiologie
Seit 11/2013: Leiter Invasive Elektrophysiologie
11/13-12/14: Funktionsoberarzt für nicht-invasive und invasive Elektrophysiologie
Seit 11/2011: Facharzt für Innere Medizin
Seit 2009: Wissenschaftlicher Arbeitsgruppenleiter
Aus- und Weiterbildung
07/2005 – 12/2020: Ruprecht Karls Universität Heidelberg
Wissenschaftlicher Mitarbeiter
30.06.2015: Ernennung zum außerordentlichen Professor
04.10.2012: Habilitation im Fach Innere Medizin
31.03.2006: Promotion (summa cum laude)
2017: Zusatzbezeichnung Interventionelle Kardiologie der DGK
2014: Zusatzbezeichnung Spezielle Rhythmologie/Invasive Elektrophysiologie der DGK
2000 – 2005: Ruprecht Karls Universität Heidelberg
Medizinische Fakultät, Klinisches Studium
Auslandsaufenthalte: Sorbonne Universtité Paris (FR), Kantonsspital Altdorf (CH)
1998 – 2000: Ludwig Maximilians Universität München, Medizinische Fakultät
Zusatzqualifikationen
2019, 2020, 2021: Listung als TOP-Mediziner für den Bereich Rhythmologie durch die Ärzteliste der Zeitschrift FOCUS
Seit 2017: Mitglied des Nukleus der Arbeitsgruppe Elektrophysiologie (AGEP) der DGK
04/2014: Sachkunde ICD-Therapie (DGK)
03/2014: Sachkunde kardiale Resynchronisationstherapie (DGK)
03/2014: Sachkunde Herzschrittmachertherapie (DGK)
Mitgliedschaften
Deutsche Gesellschaft für Kardiologie (DGK)
European Society of Cardiology (ESC)
Veröffentlichungen:
Zylla M. M., Leiner J., Rahm A-K., Hoffmann T., Lugenbiel P., Schweizer P., Scholz E., Mereles D., Kronsteiner D., Kieser M., Katus H. A., Frey No., Thomas D. Catheter Ablation of Atrial Fibrillation in Patients With Heart Failure and Preserved Ejection Fraction. Circulation: Heart Failure. 2022;0:10.1161/CIRCHEARTFAILURE.121.009281
Sager S, Bernhardt F, Kehrle F, Merkert M, Potschka A, Meder B, Katus H, Scholz E. Expert-enhanced machine learning for cardiac arrhythmia classification. PLoS One. 2021 Dec 23;16(12):e0261571.
Windisch P, Zwahlen DR, Giesel FL, Scholz E, Lugenbiel P, Debus J, Haberkorn U, Adeberg S. Clinical results of fibroblast activation protein (FAP) specific PET for non-malignant indications: systematic review. EJNMMI Res. 2021 Feb 19;11(1):18.
Veltmann C, Ehrlich JR, Gassner UM, Meder B, Möckel M, Radke P, Scholz E, Schneider H, Stellbrink C, Dunker D: Wearable-basierte Detektion von Arrhythmien-Positionspapier der Deutschen Gesellschaft für Kardiologie. Kardiologe. 2021. doi: 10.1007/s12181-021-00488-3. [Epub ahead of print]
Salatzki J, Fischer T, Riffel J, André F, Hirschberg K, Ochs A, Hund H, Müller-Hennessen M, Giannitsis E, Friedrich MG, Scholz E, Frey N, Katus HA, Ochs M. Presence of contractile impairment appears crucial for structural remodeling in idiopathic left bundle-branch block. J Cardiovasc Magn Reson. 2021 Apr 1;23(1):39. doi: 10.1186/s12968-021-00731-6. PMID: 33789682; PMCID: PMC8015193.
Wagner L, Darche FF, Thomas D, Lugenbiel P, Xynogalos P, Seide S, Scholz EP, Katus HA, Schweizer PA. Cryoballoon pulmonary vein isolation-mediated rise of sinus rate in patients with paroxysmal atrial fibrillation. Clin Res Cardiol. 2021 Jan;110(1):124-135. doi: 10.1007/s00392-020-01659-0. Epub 2020 May 13. PMID: 32405738; PMCID: PMC7806555.
Rahm AK, Lugenbiel P, Ochs M, Meder B, Thomas D, Katus HA, Scholz E. Pulmonary vein isolation treats symptomatic AF in a patient with Lamin A/C mutation: case report and review of the literature. Clin Res Cardiol. 2020 Aug;109(8):1070-1075. doi: 10.1007/s00392-020-01616-x. Epub 2020 Mar 6. PMID: 32144494; PMCID: PMC7376080.
Lehmann LH, Katus HA, Scholz EP. Rhythmusstörungen bei malignen Erkrankungen, unter Bestrahlung und Chemotherapie [Cardiac arrhythmias in oncological diseases, during radiotherapy, chemotherapy]. Herzschrittmacherther Elektrophysiol. 2019 Sep;30(3):268-273. German. doi: 10.1007/s00399-019-00634-1. Epub 2019 Aug 28. PMID: 31463582.
Seidensaal K, Harrabi SB, Scholz E, Ellerbrock M, Haberer T, Weykamp F, Mattke M, Welte SE, Herfarth K, Debus J, Uhl M. Active-Scanned Protons and Carbon Ions in Cancer Treatment of Patients With Cardiac Implantable Electronic Devices: Experience of a Single Institution. Front Oncol. 2019 Aug 22;9:798.
Scholz EP, Seidensaal K, Naumann P, André F, Katus HA, Debus J. Risen from the dead: Cardiac stereotactic ablative radiotherapy as last rescue in a patient with refractory ventricular fibrillation storm. HeartRhythm Case Rep. 2019 Mar 21;5(6):329-332. doi: 10.1016/j.hrcr.2019.03.004. PMID: 31285992; PMCID: PMC6587041.
Berkovitz A, Deneke T, Ene E, Halbfaß P, Hebe J, Hobbiesiefken S, Katus HA, Konrad T, Lange B, Marx A, Nentwich K, Neuzner J, Paliege R, Reinhardt A, Rostock T, Siebels J, Scholz EP, Sonne K. Ventrikuläre Extrasystolen und Breitkomplextachykardien [Ventricular extrasystoles and wide complex tachycardias]. Herzschrittmacherther Elektrophysiol. 2019 Mar;30(1):38-50. German. doi: 10.1007/s00399-019-0612-4. Epub 2019 Mar 8. PMID: 30848338.
Scholz EP, Fischer P, Lugenbiel P, Xynogalos P, Schweizer PA, Scherer D, Thomas D, Katus HA, Zitron E. Novel approach to discriminate left bundle branch block from nonspecific intraventricular conduction delay using pacing-induced functional left bundle branch block. J Interv Card Electrophysiol. 2018 Dec;53(3):347-355. doi: 10.1007/s10840-018-0449-5. Epub 2018 Sep 19. PMID: 30232686.
Xynogalos P, Lugenbiel P, Schweizer P, Katus H, Thomas D, Scholz EP. Butterfly and reverse butterfly: usefulness of a resistance band to provoke exercise-induced arrhythmias during catheter ablation in a patient refractory to pharmacological stimulation. Clin Res Cardiol. 2019 Jan;108(1):110-113. doi: 10.1007/s00392-018-1330-3. Epub 2018 Jul 26. PMID: 30051183.
Zylla MM, Hillmann HAK, Proctor T, Kieser M, Scholz E, Zitron E, Katus HA, Thomas D. Use of the wearable cardioverter-defibrillator (WCD) and WCD-based remote rhythm monitoring in a real-life patient cohort. Heart Vessels. 2018 Nov;33(11):1390-1402. doi: 10.1007/s00380-018-1181-x. Epub 2018 May 2. PMID: 29721674.
Lugenbiel P, Xynogalos P, Schweizer P, Katus HA, Thomas D, Scholz EP. Successful localization and ablation of a Mahaim potential using a high- resolution mapping catheter after a failed conventional ablation attempt. Clin Res Cardiol. 2018 Jul;107(7):607-610. doi: 10.1007/s00392-018-1231-5. Epub 2018 Mar 12. PMID: 29532157.
Staudacher I, Nalpathamkalam AR, Uhlmann L, Illg C, Seehausen S, Akhavanpoor M, Buchauer A, Geis N, Lugenbiel P, Schweizer PA, Xynogalos P, Zylla MM, Scholz E, Zitron E, Katus HA, Thomas D. Fully digital data processing during cardiovascular implantable electronic device follow-up in a high-volume tertiary center. Eur J Med Res. 2017 Oct 11;22(1):41. doi: 10.1186/s40001-017-0284-7. PMID: 29020984; PMCID: PMC5637082.
Scherer D, Schworm B, Seyler C, Xynogalos P, Scholz EP, Thomas D, Katus HA, Zitron E. Inhibition of inwardly rectifying Kir2.x channels by the novel anti- cancer agent gambogic acid depends on both pore block and PIP<sub>2</sub> interference. Naunyn Schmiedebergs Arch Pharmacol. 2017 Jul;390(7):701-710. doi: 10.1007/s00210-017-1372-5. Epub 2017 Apr 2. PMID: 28365825.
Seyler C, Scherer D, Köpple C, Kulzer M, Korkmaz S, Xynogalos P, Thomas D, Kaya Z, Scholz E, Backs J, Karle C, Katus HA, Zitron E. Role of plasma membrane- associated AKAPs for the regulation of cardiac I<sub>K1</sub> current by protein kinase A. Naunyn Schmiedebergs Arch Pharmacol. 2017 May;390(5):493-503. doi: 10.1007/s00210-017-1344-9. Epub 2017 Mar 22. PMID: 28331977.
Weber T, Katus HA, Sager S, Scholz EP. Novel algorithm for accelerated electroanatomic mapping and prediction of earliest activation of focal cardiac arrhythmias using mathematical optimization. Heart Rhythm. 2017 Jun;14(6):875-882. doi: 10.1016/j.hrthm.2017.03.001. Epub 2017 Mar 6. PMID: 28279745; PMCID: PMC5446561.
Koepple C, Scherer D, Seyler C, Scholz E, Thomas D, Katus HA, Zitron E. Dual Mechanism for Inhibition of Inwardly Rectifying Kir2.x Channels by Quinidine Involving Direct Pore Block and PIP<sub>2</sub>-interference. J Pharmacol Exp Ther. 2017 May;361(2):209-218. doi: 10.1124/jpet.116.238287. Epub 2017 Feb 10. PMID: 28188270.
Scholz E, Lugenbiel P, Schweizer PA, Xynogalos P, Seyler C, Zitron E, Becker R, Katus HA, Thomas D. Efficacy, High Procedural Safety And Rapid Optimization Of Cryoballoon Atrial Fibrillation Ablation In The Hands Of A New Operator. J Atr Fibrillation. 2016 Feb 29;8(5):1341. doi: 10.4022/jafib.1341. PMID: 27909474; PMCID: PMC5089487.
Scherer D, Seyler C, Xynogalos P, Scholz EP, Thomas D, Backs J, Andrassy M, Völkers M, Karle CA, Katus HA, Zitron E. Inhibition of Cardiac Kir Current (IK1) by Protein Kinase C Critically Depends on PKCβ and Kir2.2. PLoS One. 2016 May 23;11(5):e0156181. doi: 10.1371/journal.pone.0156181. PMID: 27214373; PMCID: PMC4877014.
Loewe A, Wilhelms M, Schmid J, Krause MJ, Fischer F, Thomas D, Scholz EP, Dössel O, Seemann G. Parameter Estimation of Ion Current Formulations Requires Hybrid Optimization Approach to Be Both Accurate and Reliable. Front Bioeng Biotechnol. 2016 Jan 13;3:209. doi: 10.3389/fbioe.2015.00209. PMID: 26793704; PMCID: PMC4710757.
Vonderlin N, Fischer F, Zitron E, Seyler C, Scherer D, Thomas D, Katus HA, Scholz EP. Anesthetic drug midazolam inhibits cardiac human ether-à-go-go- related gene channels: mode of action. Drug Des Devel Ther. 2015 Feb 16;9:867-77. doi: 10.2147/DDDT.S72765. PMID: 25733807; PMCID: PMC4338257.
Zylla MM, Pohlmeier M, Hess A, Mereles D, Kieser M, Bruckner T, Scholz E, Zitron E, Schweizer PA, Katus HA, Thomas D. Prevalence of intracardiac thrombi under phenprocoumon, direct oral anticoagulants (dabigatran and rivaroxaban), and bridging therapy in patients with atrial fibrillation and flutter. Am J Cardiol. 2015 Mar 1;115(5):635-40. doi: 10.1016/j.amjcard.2014.12.016. Epub 2014 Dec 18. PMID: 25591898.
Vonderlin N, Fischer F, Zitron E, Seyler C, Scherer D, Thomas D, Katus HA, Scholz EP. Inhibition of cardiac Kv1.5 potassium current by the anesthetic midazolam: mode of action. Drug Des Devel Ther. 2014 Nov 7;8:2263-71. doi: 10.2147/DDDT.S70461. PMID: 25422586; PMCID: PMC4232042.
Loewe A, Lutz Y, Wilhelms M, Sinnecker D, Barthel P, Scholz EP, Dössel O, Schmidt G, Seemann G. In-silico assessment of the dynamic effects of amiodarone and dronedarone on human atrial patho-electrophysiology. Europace. 2014 Nov;16 Suppl 4:iv30-iv38. doi: 10.1093/europace/euu230. PMID: 25362168.
Scholz EP, Raake P, Thomas D, Vogel B, Katus HA, Blessing E. Rescue renal sympathetic denervation in a patient with ventricular electrical storm refractory to endo- and epicardial catheter ablation: response to comments by Huang et al. Clin Res Cardiol. 2015 Feb;104(2):194-5. doi: 10.1007/s00392-014-0769-0. Epub 2014 Oct 15. PMID: 25315044.
Xynogalos P, Seyler C, Scherer D, Koepple C, Scholz EP, Thomas D, Katus HA, Zitron E. Class III antiarrhythmic drug dronedarone inhibits cardiac inwardly rectifying Kir2.1 channels through binding at residue E224. Naunyn Schmiedebergs Arch Pharmacol. 2014 Dec;387(12):1153-61. doi: 10.1007/s00210-014-1045-6. Epub 2014 Sep 4. PMID: 25182566.
Scholz EP, Raake P, Thomas D, Vogel B, Katus HA, Blessing E. Rescue renal sympathetic denervation in a patient with ventricular electrical storm refractory to endo- and epicardial catheter ablation. Clin Res Cardiol. 2015 Jan;104(1):79-84. doi: 10.1007/s00392-014-0749-4. Epub 2014 Aug 7. PMID: 25098585.
Fischer F, Vonderlin N, Seyler C, Zitron E, Korkmaz S, Szabó G, Thomas D, Katus HA, Scholz EP. Isoenzyme-specific regulation of cardiac Kv1.5/Kvβ1.2 ion channel complex by protein kinase C: central role of PKCβII. Naunyn Schmiedebergs Arch Pharmacol. 2014 May;387(5):469-76. doi: 10.1007/s00210-014-0965-5. Epub 2014 Feb 28. PMID: 24682423.
Loewe A, Wilhelms M, Fischer F, Scholz EP, Dössel O, Seemann G. Arrhythmic potency of human ether-a-go-go-related gene mutations L532P and N588K in a computational model of human atrial myocytes. Europace. 2014 Mar;16(3):435-43. doi: 10.1093/europace/eut375. PMID: 24569898.
Scholz EP, Kehrle F, Vossel S, Hess A, Zitron E, Katus HA, Sager S. Discriminating atrial flutter from atrial fibrillation using a multilevel model of atrioventricular conduction. Heart Rhythm. 2014 May;11(5):877-84. doi: 10.1016/j.hrthm.2014.02.013. Epub 2014 Feb 19. PMID: 24561160.
Scholz EP, Carrillo-Bustamante P, Fischer F, Wilhelms M, Zitron E, Dössel O, Katus HA, Seemann G. Rotor termination is critically dependent on kinetic properties of I kur inhibitors in an in silico model of chronic atrial fibrillation. PLoS One. 2013 Dec 20;8(12):e83179. doi: 10.1371/journal.pone.0083179. PMID: 24376659; PMCID: PMC3869770.
Fischer F, Vonderlin N, Zitron E, Seyler C, Scherer D, Becker R, Katus HA, Scholz EP. Inhibition of cardiac Kv1.5 and Kv4.3 potassium channels by the class Ia anti-arrhythmic ajmaline: mode of action. Naunyn Schmiedebergs Arch Pharmacol. 2013 Nov;386(11):991-9. doi: 10.1007/s00210-013-0901-0. Epub 2013 Jul 6. PMID: 23832378.
Fischer F, Vonderlin N, Seyler C, Zitron E, Schernus B, Katus H, Scholz E. Acute and subacute effects of the selective serotonin-noradrenaline reuptake inhibitor duloxetine on cardiac hERG channels. Naunyn Schmiedebergs Arch Pharmacol. 2013 Sep;386(9):795-804. doi: 10.1007/s00210-013-0878-8. Epub 2013 May 12. PMID: 23666493.
Wilhelms M, Rombach C, Scholz EP, Dössel O, Seemann G. Impact of amiodarone and cisapride on simulated human ventricular electrophysiology and electrocardiograms. Europace. 2012 Nov;14 Suppl 5:v90-v96. doi: 10.1093/europace/eus281. PMID: 23104920.
Kulzer M, Seyler C, Welke F, Scherer D, Xynogalos P, Scholz EP, Thomas D, Becker R, Karle CA, Katus HA, Zitron E. Inhibition of cardiac Kir2.1-2.3 channels by beta3 adrenoreceptor antagonist SR 59230A. Biochem Biophys Res Commun. 2012 Jul 27;424(2):315-20. doi: 10.1016/j.bbrc.2012.06.114. Epub 2012 Jun 27. PMID: 22749993.
Seyler C, Duthil-Straub E, Zitron E, Gierten J, Scholz EP, Fink RH, Karle CA, Becker R, Katus HA, Thomas D. TASK1 (K(2P)3.1) K(+) channel inhibition by endothelin-1 is mediated through Rho kinase-dependent phosphorylation. Br J Pharmacol. 2012 Mar;165(5):1467-75. doi: 10.1111/j.1476-5381.2011.01626.x. PMID: 21838752; PMCID: PMC3372730.
Scholz EP, Welke F, Joss N, Seyler C, Zhang W, Scherer D, Völkers M, Bloehs R, Thomas D, Katus HA, Karle CA, Zitron E. Central role of PKCα in isoenzyme- selective regulation of cardiac transient outward current Ito and Kv4.3 channels. J Mol Cell Cardiol. 2011 Nov;51(5):722-9. doi: 10.1016/j.yjmcc.2011.07.012. Epub 2011 Jul 22. PMID: 21803046.
Thomas D, Scholz EP, Schweizer PA, Katus HA, Becker R. Initial experience with robotic navigation for catheter ablation of paroxysmal and persistent atrial fibrillation. J Electrocardiol. 2012 Mar;45(2):95-101. doi: 10.1016/j.jelectrocard.2011.05.005. Epub 2011 Jun 28. PMID: 21714971.
Meder B, Scholz EP, Hassel D, Wolff C, Just S, Berger IM, Patzel E, Karle C, Katus HA, Rottbauer W. Reconstitution of defective protein trafficking rescues Long-QT syndrome in zebrafish. Biochem Biophys Res Commun. 2011 May 6;408(2):218-24. doi: 10.1016/j.bbrc.2011.03.121. Epub 2011 Mar 31. PMID: 21458413.
Scholz EP, Zitron E, Katus HA, Karle CA. Cardiovascular ion channels as a molecular target of flavonoids. Cardiovasc Ther. 2010 Aug;28(4):e46-52. doi: 10.1111/j.1755-5922.2010.00212.x. PMID: 20633021.
Gierten J, Ficker E, Bloehs R, Schweizer PA, Zitron E, Scholz E, Karle C, Katus HA, Thomas D. The human cardiac K2P3.1 (TASK-1) potassium leak channel is a molecular target for the class III antiarrhythmic drug amiodarone. Naunyn Schmiedebergs Arch Pharmacol. 2010 Mar;381(3):261-70. doi: 10.1007/s00210-009-0454-4. Epub 2009 Sep 24. PMID: 19777211.
Scholz EP, Niemer N, Hassel D, Zitron E, Bürgers HF, Bloehs R, Seyler C, Scherer D, Thomas D, Kathöfer S, Katus HA, Rottbauer WA, Karle CA. Biophysical properties of zebrafish ether-à-go-go related gene potassium channels. Biochem Biophys Res Commun. 2009 Apr 3;381(2):159-64. doi: 10.1016/j.bbrc.2009.02.042. Epub 2009 Feb 14. PMID: 19232322.
Scherer D, Hassel D, Bloehs R, Zitron E, von Löwenstern K, Seyler C, Thomas D, Konrad F, Bürgers HF, Seemann G, Rottbauer W, Katus HA, Karle CA, Scholz EP. Selective noradrenaline reuptake inhibitor atomoxetine directly blocks hERG currents. Br J Pharmacol. 2009 Jan;156(2):226-36. doi: 10.1111/j.1476-5381.2008.00018.x. Epub 2009 Jan 16. PMID: 19154426; PMCID: PMC2697834.
Zhang W, Zitron E, Bloehs R, Müller-Krebs S, Scholz E, Zeier M, Katus H, Karle C, Schwenger V. Dual regulation of renal Kir7.1 potassium channels by protein Kinase A and protein Kinase C. Biochem Biophys Res Commun. 2008 Dec 19;377(3):981-6. doi: 10.1016/j.bbrc.2008.10.110. Epub 2008 Oct 29. PMID: 18976636.
Gierten J, Ficker E, Bloehs R, Schlömer K, Kathöfer S, Scholz E, Zitron E, Kiesecker C, Bauer A, Becker R, Katus HA, Karle CA, Thomas D. Regulation of two- pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein. Br J Pharmacol. 2008 Aug;154(8):1680-90. doi: 10.1038/bjp.2008.213. Epub 2008 Jun 2. PMID: 18516069; PMCID: PMC2518462.
Scherer D, von Löwenstern K, Zitron E, Scholz EP, Bloehs R, Kathöfer S, Thomas D, Bauer A, Katus HA, Karle CA, Kiesecker C. Inhibition of cardiac hERG potassium channels by tetracyclic antidepressant mianserin. Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):73-83. doi: 10.1007/s00210-008-0289-4. Epub 2008 May 6. PMID: 18458880.
Hassel D, Scholz EP, Trano N, Friedrich O, Just S, Meder B, Weiss DL, Zitron E, Marquart S, Vogel B, Karle CA, Seemann G, Fishman MC, Katus HA, Rottbauer W. Deficient zebrafish ether-à-go-go-related gene channel gating causes short-QT syndrome in zebrafish reggae mutants. Circulation. 2008 Feb 19;117(7):866-75. doi: 10.1161/CIRCULATIONAHA.107.752220. Epub 2008 Feb 4. PMID: 18250272.
Thomas D, Bloehs R, Koschny R, Ficker E, Sykora J, Kiehn J, Schlömer K, Gierten J, Kathöfer S, Zitron E, Scholz EP, Kiesecker C, Katus HA, Karle CA. Doxazosin induces apoptosis of cells expressing hERG K+ channels. Eur J Pharmacol. 2008 Jan 28;579(1-3):98-103. doi: 10.1016/j.ejphar.2007.10.051. Epub 2007 Dec 4. PMID: 18054910; PMCID: PMC2239015.
Zitron E, Günth M, Scherer D, Kiesecker C, Kulzer M, Bloehs R, Scholz EP, Thomas D, Weidenhammer C, Kathöfer S, Bauer A, Katus HA, Karle CA. Kir2.x inward rectifier potassium channels are differentially regulated by adrenergic alpha1A receptors. J Mol Cell Cardiol. 2008 Jan;44(1):84-94. doi: 10.1016/j.yjmcc.2007.10.008. Epub 2007 Oct 18. PMID: 18035370.
Scholz EP, Konrad FM, Weiss DL, Zitron E, Kiesecker C, Bloehs R, Kulzer M, Thomas D, Kathöfer S, Bauer A, Maurer MH, Seemann G, Katus HA, Karle CA. Anticholinergic antiparkinson drug orphenadrine inhibits HERG channels: block attenuation by mutations of the pore residues Y652 or F656. Naunyn Schmiedebergs Arch Pharmacol. 2007 Dec;376(4):275-84. doi: 10.1007/s00210-007-0202-6. Epub 2007 Oct 27. PMID: 17965852.
Kelemen K, Kiesecker C, Zitron E, Bauer A, Scholz E, Bloehs R, Thomas D, Greten J, Remppis A, Schoels W, Katus HA, Karle CA. Green tea flavonoid epigallocatechin-3-gallate (EGCG) inhibits cardiac hERG potassium channels. Biochem Biophys Res Commun. 2007 Dec 21;364(3):429-35. doi: 10.1016/j.bbrc.2007.10.001. Epub 2007 Oct 9. PMID: 17961513.
Scherer D, Kiesecker C, Kulzer M, Günth M, Scholz EP, Kathöfer S, Thomas D, Maurer M, Kreuzer J, Bauer A, Katus HA, Karle CA, Zitron E. Activation of inwardly rectifying Kir2.x potassium channels by beta 3-adrenoceptors is mediated via different signaling pathways with a predominant role of PKC for Kir2.1 and of PKA for Kir2.2. Naunyn Schmiedebergs Arch Pharmacol. 2007 Jul;375(5):311-22. doi: 10.1007/s00210-007-0167-5. Epub 2007 May 30. PMID: 17534603.
Scholz EP, Zitron E, Katus HA, Karle CA, Mereles D. Atrial septal aneurysm mimicking ECG signs of enlarged right atrium. Europace. 2007 Jul;9(7):475-6. doi: 10.1093/europace/eum038. Epub 2007 May 15. PMID: 17507362.
Scholz EP, Zitron E, Kiesecker C, Thomas D, Kathöfer S, Kreuzer J, Bauer A, Katus HA, Remppis A, Karle CA, Greten J. Orange flavonoid hesperetin modulates cardiac hERG potassium channel via binding to amino acid F656. Nutr Metab Cardiovasc Dis. 2007 Nov;17(9):666-75. doi: 10.1016/j.numecd.2006.06.002. Epub 2006 Aug 22. PMID: 16926094.
Kiesecker C, Alter M, Kathöfer S, Zitron E, Scholz EP, Thomas D, Kreuzer J, Katus HA, Bauer A, Karle CA. Atypical tetracyclic antidepressant maprotiline is an antagonist at cardiac hERG potassium channels. Naunyn Schmiedebergs Arch Pharmacol. 2006 Jun;373(3):212-20. doi: 10.1007/s00210-006-0068-z. Epub 2006 May 12. PMID: 16736158.
Scholz EP, Alter M, Zitron E, Kiesecker C, Kathöfer S, Thomas D, Kreye VA, Kreuzer J, Becker R, Katus HA, Greten J, Karle CA. In vitro modulation of HERG channels by organochlorine solvent trichlormethane as potential explanation for proarrhythmic effects of chloroform. Toxicol Lett. 2006 Aug 20;165(2):156-66. doi: 10.1016/j.toxlet.2006.03.004. Epub 2006 Mar 27. PMID: 16647228.
Kiesecker C, Zitron E, Scherer D, Lueck S, Bloehs R, Scholz EP, Pirot M, Kathöfer S, Thomas D, Kreye VA, Kiehn J, Borst MM, Katus HA, Schoels W, Karle CA. Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1. J Mol Med (Berl). 2006 Jan;84(1):46-56. doi: 10.1007/s00109-005-0707-8. Epub 2005 Oct 29. PMID: 16258766.
Zitron E, Scholz EP, Kiesecker C, Pirot M, Kathöfer S, Thomas D, Kiehn J, Katus HA, Becker R, Karle CA. Molekulare Grundlagen primär elektrischer Herzerkrankungen [Molecular basis of primary electrical heart diseases]. Herzschrittmacherther Elektrophysiol. 2005 Dec;16(4):229-38. German. doi: 10.1007/s00399-005-0490-9. PMID: 16362729.
Scholz EP, Zitron E, Kiesecker C, Lück S, Thomas D, Kathöfer S, Kreye VA, Katus HA, Kiehn J, Schoels W, Karle CA. Inhibition of cardiac HERG channels by grapefruit flavonoid naringenin: implications for the influence of dietary compounds on cardiac repolarisation. Naunyn Schmiedebergs Arch Pharmacol. 2005 Jun;371(6):516-25. doi: 10.1007/s00210-005-1069-z. Epub 2005 Jul 9. PMID: 16007460.
Zitron E, Scholz E, Owen RW, Lück S, Kiesecker C, Thomas D, Kathöfer S, Niroomand F, Kiehn J, Kreye VA, Katus HA, Schoels W, Karle CA. QTc prolongation by grapefruit juice and its potential pharmacological basis: HERG channel blockade by flavonoids. Circulation. 2005 Feb 22;111(7):835-8. doi: 10.1161/01.CIR.0000155617.54749.09. Epub 2005 Feb 14. PMID: 15710766.
Kiesecker C, Zitron E, Lück S, Bloehs R, Scholz EP, Kathöfer S, Thomas D, Kreye VA, Katus HA, Schoels W, Karle CA, Kiehn J. Class Ia anti-arrhythmic drug ajmaline blocks HERG potassium channels: mode of action. Naunyn Schmiedebergs Arch Pharmacol. 2004 Dec;370(6):423-35. doi: 10.1007/s00210-004-0976-8. Epub 2004 Oct 30. PMID: 15599706.
Zitron E, Kiesecker C, Scholz E, Lück S, Bloehs R, Kathöfer S, Thomas D, Kiehn J, Kreye VA, Katus HA, Schoels W, Karle CA. Inhibition of cardiac HERG potassium channels by the atypical antidepressant trazodone. Naunyn Schmiedebergs Arch Pharmacol. 2004 Aug;370(2):146-56. doi: 10.1007/s00210-004-0952-3. Epub 2004 Jul 29. PMID: 15322737.
Thomas D, Hammerling BC, Wu K, Wimmer AB, Ficker EK, Kirsch GE, Kochan MC, Wible BA, Scholz EP, Zitron E, Kathöfer S, Kreye VA, Katus HA, Schoels W, Karle CA, Kiehn J. Inhibition of cardiac HERG currents by the DNA topoisomerase II inhibitor amsacrine: mode of action. Br J Pharmacol. 2004 Jun;142(3):485-94. doi: 10.1038/sj.bjp.0705795. Epub 2004 May 17. PMID: 15148258; PMCID: PMC1574964.
Scholz EP, Zitron E, Kiesecker C, Lueck S, Kathöfer S, Thomas D, Weretka S, Peth S, Kreye VA, Schoels W, Katus HA, Kiehn J, Karle CA. Drug binding to aromatic residues in the HERG channel pore cavity as possible explanation for acquired Long QT syndrome by antiparkinsonian drug budipine. Naunyn Schmiedebergs Arch Pharmacol. 2003 Nov;368(5):404-14. doi: 10.1007/s00210-003-0805-5. Epub 2003 Oct 14. PMID: 14557918.
Karle CA, Zitron E, Zhang W, Wendt-Nordahl G, Kathöfer S, Thomas D, Gut B, Scholz E, Vahl CF, Katus HA, Kiehn J. Human cardiac inwardly-rectifying K+ channel Kir(2.1b) is inhibited by direct protein kinase C-dependent regulation in human isolated cardiomyocytes and in an expression system. Circulation. 2002 Sep 17;106(12):1493-9. doi: 10.1161/01.cir.0000029747.53262.5c. PMID: 12234954.